The opening poem follows a bereaved speaker who tries to interpret a bird's repeated answer. The sound stays the same, but the questions become more painful. Internal rhyme, recurring phrases, and the return of the refrain make the reader hear the speaker's difficulty escaping his own thoughts.
The collection does not maintain that one emotional condition. Eulalie describes marriage as a release from loneliness. To Helen imagines beauty as a homecoming, using the language of classical travel and sculpture. The Conqueror Worm and The Haunted Palace, meanwhile, turn a theater and a royal building into images of human life and mental collapse.
Poe dedicates the book to Elizabeth Barrett Barrett, later known as Elizabeth Barrett Browning. In his preface, he says he wants the poems to circulate in the words he wrote, after alterations in the press. The later section gathers youthful work, including Sonnet—To Science, Al Aaraaf, and Tamerlane. Reading the volume in order therefore means moving backward through part of his development.